Endocrine Abstracts

Pentraxin 3 (PTX3) is an acute phase protein expressed in the advanced atherosclerotic lesions and produced by endothelial cells, macrophages and, in rodents also by adipocytes under tumour necrosis factor α (TNFα) exposure. We investigated if PTX3 is expressed in human adipose tissue and is associated with cardiometabolic risk factors.Methods: Samples of subcutaneous (SAT) and omental visceral (VAT) adipose tissue were obtained from 21 obese (...

In human adipocytes the cAMP-dependent pathway mediates signals originating from the activation of beta-adrenergic receptors, thus playing a key role in the regulation of important metabolic processes such as lipolysis and thermogenesis. CyclicAMP effects are mainly mediated by cAMP-dependent protein kinase (PKA), a tetrameric enzyme composed by two catalytic subunits associated with two regulatory (R) subunits. There are four different R subunit genes and proteins (R1A, R1B, ...